Gender dysphoria: prejudice from childhood to adulthood; but no impact in inflammation.A cross-sectional controlled study

INTRODUCTION Gender dysphoria (GD) is characterized by a marked incongruence between experienced gender and one's assigned at birth. Transsexual individuals present higher prevalence of psychiatric disorders when compared to non-transsexual populations, it has been proposed that minority stress, i.e., discrimination or prejudice, relevant impact on these outcomes. Transsexuals also show increased chances having maltreatment during childhood. Interleukin (IL)-1β, IL-6, IL-10 tumor necrosis factor-alpha (TNF-α) are inflammatory cytokines regulate our immune system. Imbalanced levels in such linked history childhood disorders. We differences IL-1β, TNF-α exposure traumatic events adulthood with without GD (DSM-5). METHODS Cross-sectional controlled study comparing 34 transsexual women 31 men. They underwent thorough structured interview, assessing sociodemographic information, mood anxiety symptoms, maltreatment, explicit suicidal ideation. Inflammatory cytokine (IL-1β, TNF-α) were measured multiplex immunoassay. RESULTS Individuals more (p = 0.002) 0.046) than Higher ideation < 0.001) previous suicide attempt rates observed women. However, no the any cytokine. CONCLUSIONS These results suggest exposed stressful from men per se does not play role markers.